Members

Senior Scientist Song-Ho Chong

EDUCATION

1994 B.S. (Chemistry) Faculty of Science, Kyoto University
1996 M.A. (Chemistry) Department of Chemistry, Graduate School of Science, Kyoto University
1999 Ph.D. (Science) Department of Chemistry, Graduate School of Science, Kyoto University

RESEARCH EXPERIENCES

1999 Postdoctoral Fellow, Technische Universität München
2002 Postdoctoral Fellow, Università di Roma
2003 Postdoctoral Fellow, Université Montpellier II
2004 Assistant Professor, Institute for Molecular Science
2010 Research Professor, Seoul National University
2011 Research Professor/Senior Researcher, Sookmyung Women’s University
2021 Senior Scientist, RIKEN Center for Biosystems Dynamics Research

AWARDS

2009 Young Scientist Award of the Physical Society of Japan (Ryoiki 12, Chemical Physics)

PROFESSIONAL AFFILIATIONS

Korean Chemical Society

RESEARCH PROJECTS

  1. Development of methods based on statistical mechanics (mainly solvation theory) and its application to biological macromolecules

PUBLICATIONS

  1. Time-dependent communication between multiple amino acids during protein folding.
    S.-H. Chong and S. Ham
    Chemical Science, 12, 5944–5951 (2021)
  2. Local environment effects on charged mutations for developing aggregation-resistant monoclonal antibodies.
    J. Lee, S.-H. Chong and S. Ham
    Scientific Reports, 10, 21191 (13 pages) (2020)
  3. Explicit characterization of the free energy landscape of pKID–KIX coupled folding and binding.
    S.-H. Chong, H. Im and S. Ham
    ACS Central Science, 5, 1342–1351 (2019)
  4. Folding free energy landscape of ordered and intrinsically disordered proteins.
    S.-H. Chong and S. Ham
    Scientific Reports, 9, 14927 (9 pages) (2019)
  5. A new computational method for protein–ligand binding thermodynamics.
    S.-H. Chong and S. Ham
    Bulletin of Korean Chemical Society, 40, 180–185 (2019)
  6. Examining a thermodynamic order parameter of protein folding.
    S.-H. Chong and S. Ham
    Scientific Reports, 8, 7148 (9 pages) (2018)
  7. Role of electrostatic interactions in determining the G-quadruplex structures.
    J. Lee, H. Im, S.-H. Chong and S. Ham
    Chemical Physics Letters, 693, 216–221 (2018)
  8. Dynamics of hydration water plays a key role in determining the binding thermodynamics of protein complexes.
    S.-H. Chong and S. Ham
    Scientific Reports , 7, 8744 (10 pages) (2017)
  9. Computer simulations of intrinsically disordered proteins.
    S.-H. Chong, P. Chatterjee, and S. Ham
    Annual Review of Physical Chemistry, 68, 117–134 (2017)
  10. Anomalous dynamics of water confined in protein–protein and protein–DNA interfaces.
    S.-H. Chong and S. Ham
    Journal of Physical Chemistry Letters, 7, 3967–3972 (2016)
  11. New computational approach for external entropy in protein–protein binding.
    S.-H. Chong and S. Ham
    Journal of Chemical Theory and Computation, 12, 2509–2516 (2016)
  12. Dissecting protein configurational entropy into conformational and vibrational contributions.
    S.-H. Chong and S. Ham
    Journal of Physical Chemistry B , 119, 12623–12631 (2015)
  13. Structural and thermodynamic characteristics of amyloidogenic intermediates of -2-microglobulin.
    S.-H. Chong, J. Hong, S. Lim, S. Cho, J. Lee, and S. Ham
    Scientific Reports, 5, 13631 (9 pages) (2015)
  14. Structural versus energetic approaches for protein conformational entropy.
    S.-H. Chong and S. Ham
    Chemical Physics Letters, 627, 90–95 (2015)
  15. Distinct role of hydration water in protein misfolding and aggregation revealed by fluctuating thermodynamics analysis.
    S.-H. Chong and S. Ham
    Accounts of Chemical Research, 48, 956–965 (2015)
  16. Thermodynamic-ensemble independence of solvation free energy.
    S.-H. Chong and S. Ham
    Journal of Chemical Theory and Computation, 11, 378–380 (2015)
  17. Site-directed analysis on protein hydrophobicity.
    S.-H. Chong and S. Ham
    Journal of Computational Chemistry, 35, 1364–1370 (2014)
  18. Protein folding thermodynamics: A new computational approach.
    S.-H. Chong and S. Ham
    Journal of Physical Chemistry B, 118, 5017–5025 (2014)
  19. Interaction with the surrounding water plays a key role in determining the aggregation propensity of proteins.
    S.-H. Chong and S. Ham
    Angewandte Chemie International Edition, 53, 3961–3964 (2014)
  20. Assessing the influence of solvation models on structural characteristics of intrinsically disordered protein.
    S.-H. Chong and S. Ham
    Computational and Theoretical Chemistry, 1017, 194–199 (2013)
  21. Conformational entropy of intrinsically disordered protein.
    S.-H. Chong and S. Ham
    Journal of Physical Chemistry B, 117, 5503–5509 (2013)
  22. Structural heterogeneity in familial Alzheimer’s disease mutants of amyloid-beta peptides.
    S.-H. Chong, J. Yim, and S. Ham
    Molecular BioSystems, 9, 997–1003 (2013)
  23. Aqueous interaction site integral-equation theory that exactly takes into account intramolecular correlations.
    S.-H. Chong and S. Ham
    Journal of Chemical Physics, 137, 154101 (17 pages) (2012)
  24. Elucidating the molecular origin of hydrolysis energy of pyrophosphate in water.
    J. Hong, N. Yoshida, S.-H. Chong, C. Lee, S. Ham, and F. Hirata
    Journal of Chemical Theory and Computation, 8, 2239–2246 (2012)
  25. Impact of chemical heterogeneity on protein self-assembly in water.
    S.-H. Chong and S. Ham
    Proceedings of the National Academy of Sciences U.S.A., 109, 7636–7641 (2012)
  26. Component analysis of the protein hydration entropy.
    S.-H. Chong and S. Ham
    Chemical Physics Letters, 535, 152–156 (2012)
  27. Atomic-level investigations on the amyloid- dimerization process and its driving forces in water.
    S.-H. Chong and S. Ham
    Physical Chemistry and Chemical Physics, 14, 1573–1575 (2012)
  28. Structural and thermodynamic characteristics that seed aggregation of amyloid-beta protein in water.
    S.-H. Chong, M. Park, and S. Ham
    Journal of Chemical Theory and Computation, 8, 724–734 (2012)
  29. Atomic decomposition of the protein solvation free energy and its application to amyloid-beta protein in water.
    S.-H. Chong and S. Ham
    Journal of Chemical Physics, 135, 034506 (8 pages) (2011)
  30. Structural and thermodynamic investigations on the aggregation and folding of acylphosphatase by molecular dynamics simulations and solvation free energy analysis.
    S.-H. Chong, C. Lee, G. Kang, M. Park, and S. Ham
    Journal of the American Chemical Society, 133, 7075–7083 (2011)
  31. Zwanzig-Mori equation for the time-dependent pair distribution function.
    S.-H. Chong, C.-Y. Son, and S. Lee
    Physical Review E, 83, 041201 (10 pages) (2011)
  32. Propagator for diffusive dynamics of an interacting molecular pair.
    S. Lee, C. Y. Son, J. Sung, and S.-H. Chong
    Journal of Chemical Physics, 134, 121102 (4 pages) (2011)
  33. Configurational entropy of protein: A combined approach based on molecular simulation and integral-equation theory of liquids.
    S.-H. Chong and S. Ham
    Chemical Physics Letters, 504, 225–229 (2011)
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